Peripheral neuropathies present as pain, numbness, tingling, and, sometimes, weakness. The initial symptoms generally depend on the nature of the underlying damage to the nerve. Odd spontaneous sensations are often the initial symptom of a peripheral neuropathy. Patients with polyneuropathies often describe the sensation that a thin layer or film is surrounding their toes or the soles of their feet.

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Burning in Bottom of Feet - Causes and Treatments
While fatigue or a skin infection can cause temporarily burning or inflamed feet, burning feet are most often a sign of nerve damage peripheral neuropathy. Nerve damage has many different causes, including diabetes, chronic alcohol use, exposure to certain toxins, certain B vitamin deficiencies or HIV infection. Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.


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Most people with RA encounter foot issues, including big toe pain, inflamed joints, and aching ankles. Learn how to minimize and soothe foot pain and stiffness. Painful feet have been a hallmark of RA for her from the start.



Peripheral neuropathy is a type of nerve damage that typically affects the feet and legs and sometimes affects the hands and arms. This type of neuropathy is very common. Up to one-half of people with diabetes have peripheral neuropathy. Over time, high blood glucose, also called blood sugar, and high levels of fats, such as triglycerides , in the blood from diabetes can damage your nerves and the small blood vessels that nourish your nerves, leading to peripheral neuropathy. You may feel extreme pain in your feet, legs, hands, and arms, even when they are touched lightly.