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Brave New World is a dystopian social science fiction novel by English author Aldous Huxley , written in and published in Largely set in a futuristic World State , whose citizens are environmentally engineered into an intelligence-based social hierarchy , the novel anticipates huge scientific advancements in reproductive technology , sleep-learning , psychological manipulation and classical conditioning that are combined to make a dystopian society which is challenged by only a single individual: the story's protagonist. Huxley followed this book with a reassessment in essay form, Brave New World Revisited , and with his final novel, Island , the utopian counterpart. In , the Modern Library ranked Brave New World at number 5 on its list of the best English-language novels of the 20th century. O wonder!

Food and Drug Administration FDA review of four large clinical safety trials shows that treating asthma with long-acting beta agonists LABAs in combination with inhaled corticosteroids ICS does not result in significantly more serious asthma-related side effects than treatment with ICS alone. In , we required the drug companies that market LABAs to conduct these trials to evaluate the safety of LABAs when used in combination with ICS, and we reviewed the results of these recently completed trials. Based on our review, the Boxed Warning , our most prominent warning, about asthma-related death has been removed from the drug labels of medicines that contain both an ICS and LABA. A description of the four trials is now also included in the Warnings and Precautions section of the drug labels. These trials showed that LABAs, when used with ICS, did not significantly increase the risk of asthma-related hospitalizations, the need to insert a breathing tube known as intubation, or asthma-related deaths, compared to ICS alone. Using LABAs alone to treat asthma without an ICS to treat lung inflammation is associated with an increased risk of asthma-related death. Therefore, the Boxed Warning stating this will remain in the labels of all single-ingredient LABA medicines, which are approved to treat asthma, chronic obstructive pulmonary disease COPD , and wheezing caused by exercise.

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